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TITLE:

RAISED HOMOCYSTEINE LEVEL IN CASES WITH ISCHEMIC STROKE

AUTHORS:

Azba Kiran, Ali Asghar, Anum Nayab

ABSTRACT:

Stroke remains one of the most devastating of all neurological diseases, often causing death or gross physical impairment or disability. Homocysteine is one of the modifiable risk factor regarding this. Objectives: To determine the frequency of raised homocysteine level in patients of ischemic stroke. Material and methods. This was a cross sectional study that was conducted at Kishwar Fazal teaching hospital Sheikhupura during January to July 2017, in which 146 cases with age range of 40 to 70 years of both gender suffering from ischemic stroke were included and were assessed for their homocysteine level. Results; In this study there were 146 cases out of which 76 (52.05%) were males and 70 (47.95%) females. The mean age was 56.25± 7.67 years and mean BMI was 29.52± 3.42. There were 40 (27.40%) cases with DM, 48 (32.88%) hypertensive, 46 (31.51%) had history of smoking while 18 (12.33%) had family history of ischemic stroke. Raised homocysteine level was seen in 58 (33.70%) cases. Raised homocysteine level was more seen in females where it was seen in 32 (45.71%) out of 70 females as compared to 26 (34.21%) out of 76 males with p values of 0.32. This raised level was also seen maximum in age groups of 60 to 70 years affecting 28 (45.14%) out of 62 cases (p=0.43). There was no significant association with any of the risk factors with raised homocysteine level. Conclusion: Ischemic stroke is a fatal condition. Raised homocysteine level is seen in every 3rd cases of ischemic stroke. Hypertension and family history of ischemic stroke has almost significant association with it. Key words: Stroke, homocysteine.

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