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TITLE:

THE POSSIBLE PROTECTIVE EFFECT OF MORINGA OLEIFERA LEAF ON AMIDARONE INDUCED PULMONARY ALVEOLAR TOXICITY IN RATS; HISTOLOGICAL STUDY

AUTHORS:

Aiman Al-Maathidy, Sinan S Farhan, Jihad Alzyoud, Aiman Al-Qtaitat*

ABSTRACT:

Abstract: Background: Moringa oleifera (Lam) has gained popularity especially in recent times due to several publications reporting various nutritional and health benefits of the plant. It has many antioxidant and anti-inflammatory properties. Conversely, Amiodarone is a chemotherapeutic drug, which has been associated with many side effects involving different organs, particularly pulmonary fibrosis. Aim of the work: The aim of this study was to investigate the protective role of Moringa oleifera against the toxic effect of amiodarone on rat pulmonary alveoli by histopathological examination. Materials and Methods: A total of 40 adult male Sprague-Dawley rats were used for the study and were randomly distributed into four groups. Group I was given normal saline (5 ml/day) for one month, group II was given Moringa oleifera leaf powder (50 mg/rat) via oral gavage daily with laboratory diet and water for one month, group III was given amidarone (30 mg/rat) via oral gavage daily for one month, and group IV was given amidarone concomitant with moringa oleifera. Results: administration of amidarone induced alteration in the pulmonary alveoli as evident by proliferation and abnormal vacuolation of type II pneumocyte, numerous foamy macrophages, intra-alveolar cellular debris and exfoliated cells, thickening of inter-alveolar septa due to mononuclear cellular infiltration, congestion of the blood vessels associated with increased collagen deposition. Concomitant administration of Moringa oleifera leaves ameliorate most of these changes. Conclusions: It could be concluded from our study that Moringa oleifera (Lam) administration could ameliorate the alveolar – toxic effect of amiodarone to the lung. Keywords: Moringa oleifera, Amidarone, Pulmonary alveoli, Lung, Histopathology

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