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TOPICAL PREPARATION: PAST, PRESENT AND FUTURE PERSPECTIVE – A REVIEW

Vrushali Rajkumar Kale, Dinesh Chhotu Pawar Pradum Pundlikrao Ige

Abstract: Topical drug delivery is defined as the application of pharmaceutical dosage form to the skin for direct treatment of cutaneous disorder or the cutaneous manifestation of the general disease, with the intent of limiting the pharmacological or other effect of the drug to the surface of the skin. The skin presents a first line of defence against a wide range of bacterial invaders. The topical route offers several advantages, including the avoidance of systemic toxicity and side effects. Topical dosage forms have been generally classified as liquids, semisolids, and solids. They contain one or more active ingredients dissolved or uniformly dispersed in a suitable base and any suitable excipients such as emulsifiers, viscosity-increasing agents, antimicrobial agents, antioxidants, or stabilizing agents. The most conventional and probably well - known topical dosage forms are creams, gels, and ointments. This review is concern with all detail information regarding approaches to topical formulations, and their permeation. Keywords: Topical drug delivery system, semisolid dosage form, skin structure, skin disease, etc

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