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ASSOCIATION OF DIABETES MELLITUS WITH PANCREATIC CANCER AND PANCREATIC CANCER MORTALITY RATE. A META-ANALYSIS REVIEW STUDY

Dr Ambreen Akhtar, Dr Hunza Binte Ather,Dr Nawal Ijaz

Abstract: Background: Diabetes mellitus (DM) is considered to be associated with risk of pancreatic cancer, however, whether DM is a cause or a result of PaC is still controversial. We examined this association and mortality rate of pancreatic cancer due to DM by conducting a detailed meta-analysis of cohort studies. Methods: Studies were identified by searching Medline and Embase. By using a random effect model summary relative risk were calculated with 95% confidence interval. Results: thirty-five cohort studies were selected in this meta-analysis. High risk of Pac (the summary RRs = 1.94; 95% CI, 1.66–2.27), with evidence of heterogeneity among these studies (p < 0.001, I 2 = 93.6%). In addition, the relative risk of PaC was correlated negatively with the duration of DM, with the highest risk of PaC found among patients diagnosed within less than 1 year. Conclusions: Findings from this meta-analysis strongly support that diabetes is associated with an increased risk of PaC in both males and females and that DM is both an early manifestation and an etiologic factor of pancreatic cancer. The death rate from pancreatic cancer was doubled in diabetics. Key words: Diabetes mellitus pancreatic cancer, type 2 diabetes, mortality and pancreatic cancer.

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