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STUDY TO KNOW THE SIMVASTATIN EFFECTS ON INSULIN SENSITIVITY IN TYPE II DABETIC PATIENTS

Dr Humna Siraj, Dr Bushra Zubair Butt, Dr Unzillah Khan

Abstract: Objective: To investigate the effect of simvastatin treatment on insulin sensitivity in type 2 diabetes mellitus patients. Study Design: A randomized case control study. Place and duration: In the Medicine Unit II of Holy Family Hospital Rawalpindi for one year duration from January 2018 to January 2019. Methods: The study was performed on 100 subjects with type 2 diabetes in both genders. Into two groups, patients were randomized. 50 subjects received Simvastatin 40 mg / day for 3 months and 50 volunteers were taken as controls. Both groups had same anthropometric properties (duration of diabetes, age, blood pressure and BMI) and biochemical (fasting plasma glucose, serum creatinine, lipid profile and fasting insulin level). Simvastatin (40 mg / day) was evaluated by insulin resistance (HOMA-IR) for the evaluation of homeostasis model for resistance of insulin after and before 3 months of management. Results: Simvastatin (40 mg / day) significantly reduced triglyceride, cholesterol and LDL levels but did not affect significantly sensitivity of insulin as determined by HOMA-IR. However, sensitivity of insulin was increased in people with resistance to insulin (P = 0.001 reduction, HOMA IR 1.92). Conclusion: Although short-term treatment with simvastatin (3 months) had no effect on sensitivity of insulin, lipid depletion had strong effect on all cases. Key words: Insulin sensitivity, Diabetes, Simvastatin, lipid profile.

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