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MOLECULAR IMAGING: FUTURE AVENUES/ FRONTIERS OF DIAGNOSTIC IMAGING

Sanawar Abbas, Liu Wenya.

Abstract: Introduction: In this study we will discuss different avenues or frontiers of molecular imaging and its future aspects. Different avenues of molecular imaging : 1-Nanotechnology: is study of extremely small things and can be applied across all the other basic sciences ranging from chemistry, biology, physics, materials science, and engineering, to handle the matter on an atomic, molecular, and supramolecular level using the principles of mechano-synthesis. 2-Aquaporin (AQPs): are members of superfamily of major intrinsic protein. Exception of aquaporin1 (EgAQP1) rest all aquaporin’s shows conserved amphipathic channel and NPA signature motifs, which suggests that EgAQPs acts both as water channels as well as other solutes channel proteins. Immunofluorescence: is the immunoassay technique for light microscopy with a fluorescence microscope that uses a detector antibody or an antigen labeled with florescent dyes to specific biomolecule targets within a cell (epitope) Discussion: The role of molecular imagine in diagnostic ultrasound has given us a new insight in to fetal anomalies. While Fluorescence imaging by furnishing a biocompatible technique using noninvasive red fluorescence imaging. New advances in conventional-CT is High-resolution Nano-CT as a radiological transformation in biomedical basic research. Another important avenue in molecular imaging of bio-sensing and diagnostics is RNA nanotechnology for processing information with molecular precision. Lu, J., et al in their study suggested next-generation intelligent MRI contrast agents by inverse contrast enhancement effect. For the purpose of diagnostic imaging of hepatic lesions magnetic resonance imaging (MRI) contrast agents braced with Iron oxide nanoparticle (IONP) have been widely employed. IVIS and MRI imaging was harnessed in mice by secreting HMGB1 in vitro and in vivo to envisage intracranial tumors. The advent of extraordinary chemical exchange saturation transfer (CEST), has enabled us to paving way for drug delivery systems based on image-guided biopolymers. Conclusion: The application of molecular imaging in the field of diagnostic imaging and clinical diagnostics are unlimited. it is important to assess the sine qua non grounding for crafting a comprehensive yet optimistic methodology for the future aspect. This encourages the future clinical researchers to devise molecular imaging probes of greater clinical significance. The correct integration of diagnostic imaging techniques and molecular approaches to make sure the best diagnostic output. Key words: Molecular, Aquaporin (AQPs), Immunofluorescence, Fluorescent probes, nanotechnology, magnetic resonance imaging (MRI).

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