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A CONCISE REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF OLANZAPINE

Vijendra P. Rathod, Rahul S. Wani, Saurabh C. Khadse, Atul A.Shirkhedkar

Olanzapine (OLZ) is an atypical antipsychotic agent is and different antipsychotic agent medications like Carbamazepine, Fluoxetine hydrochloride, Simvastatin, Clozapine, paliperidone, Quetiapine, several beta blocker, Risperidone, 9-Hydroxyrisiperidone, Demethylolanzapine, Aripiprazole, Orphenadrine, 1,2 Naphthoquinone, P-dimethylamino Benzaldehyde, Cerium sulphate, N-bromosulphinimide. The present investigation assesses the various approaches for analysis of OLZ in bulk drug as well as their pharmaceutical formulations. A concise survey states the collection and outline of about 74 explanatory strategies which incorporates HPLC, HPTLC, UV-Spectrophotometry, electrochemical techniques, LC-MS/MS, techniques actualized for examination of OLZ in biological matrices, bulk samples and in different dosage forms. The review depicts the rate usage of the different methodologies for examination of OLZ. The measurable information concerning the utility of these strategies for estimation of OLZ distributed during 1995 to 2018 have been incorporated. Keywords: Olanzapine; HPLC; HPTLC; LC–MS/MS; Spectrophotometry.

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