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A COMPREHENSIVE STUDY ON THE ROLE OF GHRELIN IN OBESITY AMONG LOCAL POPULATION OF PAKISTAN

Dr Muhammad Asim Shahzad, Dr Muhammad Shakeel, Dr Muhammad Hafeezullah

Abstract: Introduction: Obesity is a major public health problem as more than 10% of the global population is obese. The number of patients affected by this modern epidemic and the associated co-morbidities, such as diabetes mellitus, cardiovascular diseases and cancer, are constantly rising, along with the associated health costs, making the management of obesity one of paramount importance. Objectives of the study: The main objective of the study is to analyze the role of Ghrelin in obesity among local population of Pakistan. Methodology of the study: This cross sectional study was conducted in Health department of Punjab during April 2018 to October 2018. The data was collected from 100 patients. The age range for this study was 10 to 25 years. Subjects with known history of Diabetes mellitus, malignancy and major abdominal surgery and on any major Drug e.g metocloperamide will be excluded from participating in the study. A fasting venous blood sample with a total volume of 4 ml will be collected from each study participant. One ml of this will be used in for routine testing FBS and 1 ml for fasting lipid profile. Results: The data was collected from 100 patients of both genders. Mean age of hypertensive obese was 43.42 ± 10.466 years and mean age of normotensive was 35.28 ± 7.876 years. Mean ghrelin levels in hypertensive obese was 0.572±0.514 and mean ghrelin levels in normotensive obese was 0.387 ± 0.202. Statistically significant difference of mean fasting ghrelin levels between hypertensive obese and normotensive obese was noted with p value 0.013. Conclusion: It is concluded that Ghrelin was positively associated in obese patients and this association was inversely influenced by the increase of BMI.

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