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TITLE:

COMPARATIVE EVALUATION OF DIFFERENT BRANDS OF CEFIXIME TRIHYDRATE 100 MG DISPERSIBLE TABLETS IP

AUTHORS:

Madhavi M.Namanwar *, Rifaqat A Sharif, Barka K Goyanka, Almas K Hanafee, Gunapriya S Shunkapaka

ABSTRACT:

Abstract: Objective: The objective of the study was to carry out the evaluation tests and compare evaluation parameters for different marketed brands of Cefixime as Trihydrate 100 mg dispersible tablets IP. Methods: Five different brands were randomly selected for this study, which were coded as brand A, brand B, brand C, brand D and brand E. different evaluation tests were performed and compared. The tests for Hardness, friability, weight variation, wetting time, test for uniformity of dispersion and In-vitro Disintegration test, were performed and compared. Results: The important criteria for dispersible tablet to comply with regulatory requirements are to pass in the disintegration test and test for uniformity of dispersion. Based on the study, all the selected brands passed the disintegration test. However among the five brands brands A, B & D passed for test for uniformity of dispersion, whereas rest of brands i.e., C & E did not pass for test for uniformity of dispersion. Conclusion: Based on evaluation parameters data, brand D was found to be the best and superior among the selected brands of Cefixime Trihydrate 100 mg dispersible tablets, if price of tablets also considered then brand B be the best at low price among all brands with specified qualities. Key words: Brands, Dispersible Tablets, Cefixime Trihydrate, Disintegration Test and Uniformity of Dispersion

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