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ANALYSIS OF LEVEL OF PLASMA OBESTATIN LEVELS IN OBESITY AMONG LOCAL POPULATION OF PAKISTAN

Dr Aneeza Ilyas, Dr Iram hassan, Dr Mariam Iftikhar

Abstract: Introduction: Obestatin is a recently discovered peptide produced in the stomach, which was originally described to suppress food intake and decrease body weight in experimental animals. Objectives of the study: The basic objective of the study is to analyze the level of plasma obestatin levels in obesity among local population of Pakistan. Methodology of the study: This cross sectional study was conducted in Services Institute of Medical Sciences, Lahore during April 2018 till October 2018. The data was collected from 100 obese patients which was also suffering from heart and cholesterol diseases. The data was collected through a questionnaire which include all the socio-demographic factors. Body mass index (BMI) and waist circumference (WC) were done for patients and controls as anthropometrical tests, while fasting serum glucose (FSG) measured using spectrophotometric technique. Each serum sample was analyzed for obestatin hormone and fasting insulin using enzyme linked immune sorbent assay (ELISA). Results: The data was collected from 100 participants. Mean fasting obestatin levels was 0.450 ± 0.468 and 0.959 ± 0.889 respectively in hypertensive and normotensive obese and the difference of mean fasting obestatin levels between the both groups was statistically significant with p value 0.000. Mean fasting blood cholesterol level was 206.42 ± 44.420 and 202.39 ± 48.344 respectively in normal and obese and the difference was not statistically significant with p value 0.644. Conclusion: It is concluded that obestatin levels are directly correlated with blood glucose level. Furthermore, there was a clear relationship between obestatin and both BP and HOMA-IR, suggesting that obestatin might play a role in BP regulation.

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