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TITLE:

THE EFFICACY OF AESCIN ON DIABETIC NEPHROPATHY: A STREPTOZOTOCIN-INDUCED DIABETIC RAT MODEL

AUTHORS:

Shazia Parveen Channar, Kumayl Abbas Meghji, Muhammad Saqib Baloch, Sana Kashif, Ali abbas, Muhammad Shahab Hanif

ABSTRACT:

Abstract: Introduction: Hyperglycemia triggered by diabetes can cause damage to the kidney making the renal filters leaky. Cytokines like transforming growth factor β1 and raised oxidative stress in the body are believed to be accountable for the generation of Diabetic Nephropathy. Objective: To observe the ameliorative effect of Aesculus hippocastanum (AH) drug in streptozocin induced diabetic nephropathy in albino wister rats. Materials And Methods: Twenty one albino wister rats were included and divided in to three groups, control, diabetes and diabetes + Aescin. The control group received normal diet. Both the diabetes groups were induced diabetes by administration of streptozocin injections intraperitoneally. No drug was given to diabetes group while diabetes + Aescin group received drugs for 4 weeks. At the end of experiment, the glomerular area was assessed, severity of sclerosis was observed and levels of malondialdehyde, TGF- β1, blood urea and sugar levels and creatinine were analyzed. Results: The results showed that glomerular regions, sclerosis intensity, levels of malondialdehyde, TGF- β1, blood sugar, urea, and creatinine were found to be reduced in the diabetes + Aescin group. It is believed that raised blood sugar levels induce diabetic nephropathy. Aesculus hippocastanum extract improved diabetic nephropathy without lowering blood sugar level. Conclusion: Aesin is found to have positive role on the functional status of kidney and histological betterment in diabetic nephropathy. Keywords: Aesin, kidneys, diabetic nephropathy, rats, oxidative stres

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