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PHYTOCHEMICAL INVESTIGATION AND ANTIEPELEPTIC ACTIVITY OF ERYTHERINA SUBEROSA

Eiman Fatima, G. A. Miana* and Madiha Kanwal

Abstract: This study presents the phytochemical investigation of leaf extract of the plant Erythrina suberosa and antiepileptic activity by using PTZ (pentylene tetrazole) model. Almost 50 million people around the world are suffering from chronic epileptic disorder with or without appearance of convulsions on the physique. Severe side effects results upon long term uses of synthetic antiepileptic drugs and addiction obligations as well. Thus, the researchers around the globe are searching for different natural resources. Erythrina suberosa is a traditional medicinal plant used to treat seizures. Phytochemical investigation by GCMS method showed the presence of alkaloids, triterpenoids, flavonoids, sterols, proteins and phenols. The present studies reveals the anti convulsant activity of methanolic leaf extract of Erythrina suberosa by using PTZ induced convulsions model in mice successively. However, the anticonvulsant activity of this specific specie of plant has not been studied in depth. In Pentylene tetrazole (PTZ) model test, parameters like onset of tonic convulsions, myoclonic convulsions and duration of tonic-clonic convulsions were observed in the different test groups. In conclusion, we presented that the methanolic extract of Erythrina suberosa has anticonvulsant effect in the model, suggesting their possible anticonvulsant action in the central nervous system gave significant protection (P<0.001) against PTZ induce convulsion. Keywords: Erythrina suberosa, antiepileptic, phytochemical, PTZ induce convulsions, methanolic leaf extract

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