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TITLE:

POST LAPAROSCOPIC CHOLECYSTECTOMY, TRANSIENT DERANGEMENT OF LIVER ENZYMES

AUTHORS:

Muhammad Salman, Yamna Khalid, Dr Maham Habib

ABSTRACT:

Aims: We intend to enquire the change in blood levels of aspartate aminotransferase(AST), gamma-glutamyl-transferase (GGT), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALP) in patients who underwent laparoscopic cholecystectomy (LC) and collate these alterations with those happening after open cholecystectomy (OC). Methods: Out of total 194 patients studied in May 2016 to April 2017, 156 underwent laparoscopic cholecystectomy while 58 had undergone open cholecystectomy during the same period of time. OC patients were enrolled as control group. Lab investigations were done within 24 hours preoperatively and again after 24 hours postoperatively for biochemical evaluation. Results: Statistical analysis brings to light a significant increase in the levels of ALT, GGT, AST, and LDH levels in the laparoscopic cholecystectomy group postoperatively. In comparison with the open cholecystectomy group, the variation between elevations of enzymes levels was also pronounced for LC group. Conclusion: It is thus concluded that these elevations of levels of enzymes could mostly be associated to the damaging effects of the pneumoperitoneum on the blood flow of liver. Although these alterations are transient and do not seem to be clinically significant, attention should be given before planning to perform LC in patients with liver insufficiency. Key words: Laparoscopic cholecystectomy – pneumoperitoneum - liver function tests.

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