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TITLE:

FORMULATION AND INVITRO EVALUATION OF FAST DISINTEGRATING TABLETS OF AN ANTI-INFLAMMATORY DRUG

AUTHORS:

C. Haranath*, T. Srikanth, M. Suresh Krishna, G. Chaithanya Barghav, C. Mahesh Reddy

ABSTRACT:

Abstract: Oral disintegrating tablets are defined as the tablets that disperse or disintegrates in less than one minute in the mouth prior to being swallowed, which results in the rapid dissolution and absorption of the active pharmaceutical ingredient contained in the tablet, providing rapid onset of action. Aceclofenac is a poorly water-soluble drug. The solubility of the drug was enhanced by solid dispersion technique using mannitol as the carrier. In the present study, 9 formulations were developed by using different super disintegrants like cross povidone, sodium starchglycolate and cross carmellose sodium in various ratios. The tablets were prepared by direct compression method and evaluated for precompression parameters like bulk density tapped density,angle of repose, compressibilityindex, Hausner's ratio, and post-compression parameters like hardness, friability,drugcontent, disintegration, and dissolution. The results were found to be satisfactory.Tablets which were prepared by cross povidone 5%(F9 formulation) showed the best results.The percentage of drug release was found to be 98.23% at 30 minutes and disintegration time was found to be 17 seconds. Keywords: Oral disintegrating tablets,aceclofenac,solid dispersions ,super disintegrants.

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