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PREVALENCE, RISK FACTORS AND OUTCOMES OF ACUTE KIDNEY INJURY IN PATIENTS WITH BURN. A META-ANALYSIS STUDY

Dr. Mina Amer, Dr. Usama Saeed, Dr. Ibn-e-Hassan

Abstract: Aim of study: Acute kidney injury (AKI) is a fatal complication of burn injury. The aim of the study is to determining the prevalence, risk factors, and outcomes of AKI in patients with burn injury. Method: An electronic search (up to 2017) was performed using Pubmed, Embase, Medline, Web of Knowledge, and the Cochrane Library databases. Finally, a total of 18 articles (nine prospective cohort, seven retrospective cohort, two case–control) met the inclusion criteria. Results: The pooled incidence of AKI was 39.6% (95% confidence interval = 34.7–44.4%). Important risk factors for the occurrence of AKI included age (OR = 3.78 1.28–6.27), TBSA (OR = 15.66 [11.01–20.31]), full-thickness TBSA (OR = 15.66 [11.01–20.31]), flame burn (OR = 1.56 [1.09–2.25]), inhalation injury (OR = 2.97 [1.80–4.89]), abbreviated burn severity index on admission (OR = 2.42 [1.87–2.98]), sequential organ failure assessment score on admission baseline blood urea nitrogen (OR = 2.11 [0.72–3.51]), serum creatinine (OR = 2.69 [1.39–3.98]), and sepsis (OR = 4.42 [1.75–11.18]). Additionally burn patients with AKI are more likely to have long stay in intensive care unit and high mortality rate. Conclusion: AKI is a common complication and occurs at a remarkable rate in burn patients. 10 independently variables as risk factors for the development of AKI in burn patients were identified. Key words: Acute kidney injury Burns Thermal injury Meta-analysis Mortality.

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