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AN OBSERVATIONAL STUDY TO EVALUATE EFFECT OF SIX-MONTH USE OF ORAL CONTRACEPTIVE PILLS ON PLASMINOGEN ACTIVATOR INHIBITOR-1 & FACTOR VIII AMONG WOMEN WITH POLYCYSTIC OVARY SYNDROME

Fahad Qureshi, Dr.Rashmeen Khan Afridi, Dr.Sidra Ashraf

Abstract: Polycystic ovary disorder (PCOS) is an endocrinopathy, a lasting individualized treatment through way of life pharmacological specialists and, over every oral prophylactic (OCP), legitimizes. The point of this examination was to explore the impacts of OCP on plasminogen-1 inhibitor-activator (PAI-1) and on factor VIII (FVIII) in PCOS ladies for a half year. Strategies: Women with PCOS analyzed in Rotterdam 2003 criteria, regardless of whether OCP (ethinyl estradiol 0.03 mg, 0.15 mg levonorgestrel) for a time of a half year (n = 40) or medications (n = 42), were incorporated into this investigation. Blood was taken to evaluate glucose, insulin levels and lipid profile. Chemiluminescent immunoassays (LH, FSH, PRL, T4) were utilized to gauge hormones. Plasma dimensions of PAI-I and FVIII were estimated with business packs. Results: the consistency of monthly cycle, the Ferriman-Gallwey score and serum absolute testosterone improved fundamentally in the OCP bunch contrasted with the gathering without medications (P <0.01). No noteworthy contrasts were seen in the PAI-1 dimensions of the two gatherings; In the OCP gathering, be that as it may, a huge reduction in FVIII levels was watched contrasted with the gathering without medications. PAI-1 dimensions of the OCP bunch related decidedly with two-hour glucose, triglycerides and insulin two hours while the FVIII bunch OCP level associated adversely with fasting insulin and insulin opposition for homeostatic model. Elucidation and conclusion: the utilization of OCPs differently affects markers that advance coagulation in ladies with PCOS. To elucidate the adequacy and wellbeing of OCP in the treatment of PCOS, well-planned, long haul, forthcoming and enormous scale considers are required.

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