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TITLE:

CONSEQUENCE OF VENOUS CLONIDINE ON HEMODYNAMIC VARIATIONS IN LAPAROSCOPIC CHOLECYSTECTOMY: THE RANDOMIZED REGULATE RESEARCH

AUTHORS:

Dr. Nimra Saeed, Dr. Irtaza Arshad, Dr. Bushra Gul Niazi

ABSTRACT:

Abstract: Background: Laparoscopic operation remains related through substantial hemodynamic also pathophysiological vicissitudes owing to formation of pneumoperitoneum. Clonidine remains identified to constrain catecholamine also vasopressin announcement throughout pneumoperitoneum. The current randomized, measured research remained showed to assess consequence of management of venous clonidine for regulator of hemodynamic replies throughout laparoscopic operation also to appraise obligation of propofol throughout laparoscopic operation. Methodology: Overall 70 cases experiencing elective laparoscopic cholecystectomy remained randomized from September 2017 to March 2018 at Mayo Hospital Lahore into Set-C (clonidine set) also Set-S (saline set). In clonidine set respondents acknowledged 4μg/kg of clonidine diluted in 11 ml saline concluded 12 min, whereas in saline set respondents acknowledged 11 ml saline. Introduction of anesthesia remained identical in mutually sets. Heart Rate, systolic, diastolic BP also average major heaviness remained restrained beforehand premedication, beforehand introduction, afterward intubation, beforehand CO2 insufflation, afterwards insufflation also then afterward at 18 minutes intermission till exsufflation also afterwards extubating. Propofol obligation remained designed in mutually sets. Statistical Analysis: Unpaired ‘T’ examination remained exercised to associate together sets. Verdict of smearing unpaired t-test stayed grounded on ordinariness exam. Results: HR, systolic, diastolic also average major BP remained expressively fewer in clonidine set as associated to regulator set. Intraoperatively here remained substantial HR difference in regulator set 83.94 ± 7.54/min to 97.14 ± 7.81/min than in clonidine set 87.31 ± 10.13/min to 74.14 ± 9.52/min (P<0.002). Average BP diverse from 95.52 ± 5.83 mmHg to 103.19 ± 6.57 mmHg in regulator set whereas in clonidine set this diverse from 95.15 ± 8.83 mmHg to 73.63 ± 2.88 mmHg. (P<0.002). Propofol prerequisite remained expressively fewer in clonidine set. Conclusion: Management of clonidine weakens hemodynamic answer to pneumoperitoneum also decreases necessity of propofol. Key words: Clonidine, Propofol, Laparoscopic operation, Pneumoperitoneum.

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