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TITLE:

ANALYSIS OF LEVEL OF MATERNAL SERUM TRIGLYCERIDES IN WOMEN WITH PRE-ECLAMPSIA

AUTHORS:

Sadia Noor Hussain, Zarnab Zahra, Sana Rafique

ABSTRACT:

Abstract: Introduction: Maternal metabolism in late pregnancy is catabolic, with increasing insulin resistance, decreased adipose tissue lipoprotein lipase (LPL) activity, and increased lipolysis. Aims and objectives: The main objective of the study is to analyse the level of maternal serum triglycerides in women with pre-eclampsia. Material and methods: This cross sectional study was conducted in Lahore general hospital, Lahore during October 2018 to January 2019. The data was collected from 120 female patients. The age range was 20 to 40 years. Eclampsia was diagnosed in previously normotensive women with two repeat (at least 4 h apart) diastolic blood pressure measurements of 90 mmHg or greater after the 20th week of gestation. A total volume of 5 ml of venous blood was drawn from the antecubital vein. The sera after separating from blood samples were stored at −80°C until further analysis. Serum triacylglycerol was estimated by the enzymatic colorimetric method (GPO-PAP), using kit method. Results: The data was collected from 120 pregnant females. The mean age was 25.67±3.45 years. Mean serum triglyceride concentartions in pre-eclamptic and controls normal pregnant women were 3.1 (0.8) mmol/l and 2.5 (0.9) mmol/l respectively. There was significantly high serum triglyceride concentration (P < 0.01) in the pre-eclamptic group than in the normal pregnant women. No significant differences were observed in other measured lipid profile including total cholesterol, HDL and LDL. Conclusion: It is concluded that total cholesterol, triglyceride, non-HDL-C, and HDL-C levels measured during pregnancy are significantly related to the risk of preeclampsia.

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