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SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND CYTOTOXIC EVALUATION OF SOME NOVEL CHALCONES OF 2-FLUOROACETPHENONE

Prof. Vedula Girija Sastry, Prof. Yejella Rajendra Prasad, Dr. Suryadevara Vidyadhara, Dr. Vutla Venkata Rao

Abstract: Chalcones have been considered molecules of great interest considering the multiple methods of synthesis and several starting materials from which they can be synthesized yielding many different molecules. Chalcones are also known to exhibit a wide variety of pharmacological activities and hence are the molecules of great research value in medicinal chemistry. Chalcones also are intermediates for many heterocyclic and other medicinal compounds. In the present research, an attempt was made to synthesize some newer chalcones and evaluate them for their biological activities viz., antibacterial, antifungal activities and cytotoxicity. All the molecules synthesized were characterized and analysed using FTIR and 1H NMR Spectroscopic techniques. Key words: Chalcones, Antibacterial activity, Antifungal Activity, Cytotoxicity

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