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SYNTHESIS OF HETEROCYCLIC HYDRAZONE SCHIFF BASE AND ITS ZN(II) COMPLEX: SPECTROSCOPIC CHARACTERIZATION, XRD, THERMAL, ANTIBACTERIAL, AND ANTIFUNGAL EVALUATION

Gajanan Dongare and Anand Aswar

Abstract: New hydrazone ligand of 2-hydroxybenzylidene-4-oxopiperidine-1-carbohydrazone (H2L) was designed and synthesized by the condensation reaction of 4-oxo-1-carboxopiperidone hydrazide with 2-hydroxy benzaldehyde. This ligand was reacts with Zn(II) chloride salts to obtained [Zn(L)(H2O)]complex.The ligand was characterized by elemental and spectral techniques such as Infrared, UV-vis, 1H and 13C NMR, mass) and supporting analysis molar conductance, magnetic susceptibility, powder XRD, TG analyses also performed for the confirmation of structure. The ligand and metal stoichiometric ratio found as 1:1 (M:L) in the complex. The ligand behaves as a dibasic tridentate, coordinating through the Ophenolate, Nazomethine, Oenolate donor functionality towards Zn(II) complex. The spectral, thermo-analytical data displays tetrahedral geometry for all complexes. X-ray diffraction study confirms nanocrystalline nature of ligand and its metal complexes. The kinetic parameters were evaluated by Coats- Redfern method indicated complex shows higher degree of thermal stability. The newly synthesized (2HL) ligand and Zn(II) complex were biologically screened for its antibacterial efficiency against gram-negative bacteria (Escherichia coli and Salmonella typhi), gram-positive bacteria (Staphylococcus aureus and Bacillus substillus) and the fungal efficiency against pathogens (Candida albicans and Aspergillus niger) and obtained data show that metal complexes are more competent than the parent ligand against bacterial species. Keywords: Hereocyclic hydrazone, XRD, Antifungal and antimicrobial activities, Thermal properties.

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