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FORMULATION AND EVALUATION OF TOPICAL SOLUTION OF TRANEXAMIC ACID AS NASAL SPRAY

Sudarshan Jagtap* , Dr. Nayan Gujarathi

Tranexamic acid is an Hemostatic agent which acts by blocking the conversion of plasminogen to plasmin which is required in the formation of blood clot as shown in following diagram. It is Available in tablet, injection and Mouthwash form in market for the treatment of bleeding cases; an attempt was made to prepare and evaluate Nasal spray containing Tranexamic acid as a Active ingredient and Sodium CMC was used as mucoadhesive polymer to increase the contact time of formulation as , in nose bleeding the flow of blood is there and to avoid the washout of drug from site of action this is necessary to increase the contact time by increasing the viscosity of formulation by using the mucoadhesive polymer. and form artificial net to stop bleeding by trapping blood cells (RBC Etc.).Various formulations were prepared by using different concentrations of Sod. CMC and the best formulation were optimized by checking the spray property and contact time of each trial batch. The prepared Formulation were evaluated for their physicochemical parameters such as physical appearance, pH, Viscosity, Assay (drug content uniformity), In-vitro permeation, Spray property, In-vitro permeation, Droplet size distribution, Pump Delivery, and contact time. A 61 full factorial design was applied to the formulations containing different concentration of polymer . From factorial design batches (F0-F5) the batch with Good sprayability and higher contact time(F3) were considered as optimized batch. Finally it can be concluded that the nasal spray of tranexamic acid were formulated and evaluated successfully for treatment of epistaxis, Accidental and operative bleeding. Keywords: Tranexamic acid, Sod. CMC, Hemostatic, RP-HPLC,Epistaxis.

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