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REVIEW ON HYPHENATED ANALYTICAL TECHNIQUES IMPLEMENTED FOR ANALYSIS OF ROSUVASTATIN

Atul A. Shirkhedkar, Pankaj D. Mahajan, Amod S. Patil,

Rosuvastatin calcium [RSV] specifically inhibit the enzyme 3-hydroxy-3-methylglutaryl-Co-enzyme A [HMG-CoA] reductase. It belongs to family of cholesterol lowering medications which are denoted as statins and useful in treatment of dyslipidemia where it helps in reducing the chances of arthrosclerosis development by decreasing the level of bad cholesterol and hence eliminating the possibilities of heart diseases. RSV was developed by Astra-Zeneca and it was granted approval in 2003 by US-FDA. This article presents a literature review on hyphenated analytical techniques implemented for the estimation of RSV in pharmaceutical preparations and biological fluids. Keywords: Analytical methods; LC–MS/MS; GC-MS; CE-MS; LC-NMR; Rosuvastatin.

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