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TITLE:

ANALYSIS OF PHYSIOLOGICAL CHANGES IN THE LIVER AFTER USING PARACETAMOL EXCESSIVELY AMONG LOCAL POPULATION OF PAKISTAN

AUTHORS:

Dr Afzal Hussain, Dr Ayesha Shaheen, Dr Saira Ibrahim

ABSTRACT:

Introduction: The liver plays a part in many important functions in the body including metabolism, detoxification, and bile secretion. Additionally, it provides protection from exposure to foreign substances by detoxifying and eliminating them. Aims of the study: The basic aim of the study is to analyze the physiological changes in the liver after using paracetamol excessively among local population of Pakistan. Material and methods: This cross sectional study was conducted in District Head Quarter Hospital Hafizabad during January 2018 till May 2018. This study was done with the permission of ethical research committee of the department. The data was collected from 50 patients who were using the paracetamol excessively. 5ml blood was taken for further analysis. Blood was centrifuged at 4000 rpm for 10 minutes and serum was separated. Serum liver enzymes (AST, ALT and ALP) and serum Total protein level were estimated by using Human Diagnostic enzymatic kits. Results: There was a significant increase in collagen fiber accumulation in the second and third week sections and a non-significant increase in the first week sections of the high-dose paracetamol group compared with the control group. In the control group, sections showed a normal histological pattern with seminiferous tubules and a narrow interstitium in between them. Liver histology shows that liver cell lines were destroyed mainly due to the excessive use of paracetamol. Conclusion: It is concluded that paracetamol is harmful to the liver when consumed in large repeated doses. Thus, it should be used with caution, especially when a large and prolonged dose is indicated.

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.