::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

LEVELS OF ANTIOXIDANTS IN THE BLOOD WITH THE USE OF ROPIVACAINE FOR GENERAL ANESTHESIA

AUTHORS:

Dr Zunaira Fatima, Dr Safi Ullah Sardar, Dr Kaleem Asad

ABSTRACT:

Objectives of the study: The main objective of this study is to find the level of antioxidants in blood with the use of Ropivacaine for general anesthesia. Materials and methods: This cross sectional study was conducted at Ibne Sina hospital, Multan during October 2019 January 2020. 50 patients were selected to study the effect of ropivacaine. 5.0 ml blood sample was taken to measure the levels of lipid peroxidation (MDA), glutathione (GSH), SOD and Catalases before anaesthesia (0 min), and at 5, 30 and 60 minute after anaesthesia. Commercially available enzymatic kits of Randox were used. Results: Mean values of investigated parameters and diﬀerences in the values between, before and after anaesthesia are represented in the table 01. The values are expressed in terms of mean± SD. According to the analysis, the level of SOD, MDA and GSH increase as compared to normal level. But the level of catalases decreased with the value of 0.43±0.39 (after 5 minutes of anaesthesia). Conclusion: In conclusion, we found that while spinally injection of ropivacaine increased free radical levels in the blood.