Dr Zunaira Fatima, Dr Kaleem Asad, Dr Safi Ullah Sardar
Objectives of the study: To compare the frequency of Ovulation Induction after administration of Letrozole with metformin in females presenting with Polycystic Ovarian Syndrome. Methodology of the study: This descriptive study was conducted at Ibne Sina Hospital, Multan during June 2019 to January 2020. Total 200 females fulfilling the inclusion criteria were recruited from OPD. Then random ordering of females was done in 2 groups by utilizing lottery method. Females in A-group were given Letrozole 2.5mg once a day for three days (from third day to seventh day ) for three cycles and metformin 1500mg (500mg 3 times a day) daily for three months, while females in group Both BMI & age were studied for Mean & S.D. Ovulation induction was studied and Percentage along with frequency was calculated. Results: In Group-A mean age of women was 28.18±6.58 years. In Group-B mean age of women was 27.08±5.15 years. In Group-A ovulation induction rate was significantly higher as compared to that of Group-B women. i.e. (89% vs. 60%). p-value=0.000. Ovulation induction rate was significantly higher with Letrozzole+ Metformin in women who were having normal BMI, overweight & obese as compared to that of Letrozzole alone. Conclusion: Letrozole with metformin is more effective for the ovulation Induction females presenting with polycystic ovarian Syndrome as compared to letrozole alone.