- CODEN : IAJPBB
- issn 2349-7750
TITLE:
EVALUATION OF FSH, LH AND MDA IN POLYCYSTIC OVARIAN SYNDROME PATIENTS FROM LAHORE PAKISTAN
AUTHORS:
Hina Mumtaz, Hafiz Muhammad Arsalan, Zeemal Seemab Amin1, Munib Ashfaq, Iqra Maqsood
ABSTRACT:
Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder in reproductive age of women categorized by hyper-androgenism, chronic ovulation and menstrual disturbance. Obesity, infertility, and insulin resistance are the major sign and symptoms of all these three indications. PCOS can be diagnosed by occurrence of 12 or more follicles which diameter is about 2 to 9 mm and or on transvaginal ultrasound study raised volume is about >10cm3. About 6-8% population of women disturb by PCOS. Objectives: To evaluate the level of different hormones FSH, LH and Malondialdehyde status in polycystic ovary syndrome patients. Methodology: Venous blood (5.0 ml) samples of 50 polycystic ovary syndrome patients and 50 blood samples (5.0 ml) of control individuals were taken in clotted gel vials. Blood serum was further processed for the estimation of Follicle stimulating hormone (FSH), Luteinizing hormone (LH), Malondialdehyde (MDA), Advanced Glycation End products (AGE’s) , Nitric oxide (NO), serum liver function tests (LFT’s), Lipid Profile, and Renal Profile by using spectrophotometer. Results: Level of AGE’s in control (1.05) and in diseased patients (1.38), level of MDA in control (3.15) and in diseased patients is (0.88) and level of LH significantly increase in patients (10.81) as compare to healthy individuals (8.45) also level of FSH is decrease in patients (14.65) as compare to control individuals (19.34). Serum hepatic profile status reveals that level of value of bilirubin elevate in diseased patients (0.58) as compare to healthy persons(0.42) while SGOT level in diseased individuals raise (47.62) as compare with healthy persons (40.12) and level of SGPT also elevate in diseased persons (52.97) as compare with control persons (43.12). All parameters showed statistically significant (P=0.00 <0.05). Conclusion: PCOS is an endocrine disorder at reproductive age of women. It is the major cause of infertility which also correlate with other metabolic disorders. PCOS mainly recognized by hyperandrogenism, irregular periods and presences of cysts. Key Words: PCOS, FSH, LH, MDA, SGOT, Bilirubin and SGPT
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NLM ID:101711216 [Serial]
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ICV 2015 - 61.16
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cosmos Impact Factor:4.153
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