Dr Aaiz Hassan, Dr Muhammad Faheem, Dr Kh. Raees ur Rehman
Background: Helicobacter pylori disrupts iron and vitamin B12 metabolism, causing gastritis. These two micronutrient deficiencies interfere with the normal morphological properties of red blood cells, making them fragile. When such red blood cells pass through narrow circulating places, such as the red spleen pulp, they rupture. Aim: The purpose of this study is to explain the effect of Helicobacter pylori infection on the fragility of red blood cells. Place and Duration: In the Medicine Unit II of Services Hospital Lahore for one year duration from January 2019 to January 2020. Methods: The study covered 90 people. Group A (30 patients with gastric symptoms and H. pylori infection symptoms) and group B (30 patients with gastric symptoms but without H. pylori infection) and group C (30 patients with normal healthy age and sex). H. pylori infection was considered positive on the basis of positive serology, rapid urease test and histopathological examination. Brittleness of red blood cells was determined by osmotic fragility using different saline concentrations. Results: The fragility of red blood cells did not differ significantly between groups or compared to each other (p-value> 0.05). Conclusion: H. pylori infection did not affect red blood cell fragility. Key words: red blood cell fragility, Helicobacter pylori.