- CODEN : IAJPBB
- issn 2349-7750
TITLE:
PREVALENCE OF LIPID PEROXIDATION AND HEPATIC PROFILE IN HEPATITIS C PATIENTS RECEIVING SOFOSBUVIR AND RIBAVIRIN FROM LAHORE-PAKISTAN
AUTHORS:
Zeemal Seemab Amin, Iqra Maqsood, Hafiz Muhammad Arsalan, Munib Ashfaq, Hina Mumtaz
ABSTRACT:
Background: Hepatitis C Virus is a member of flaviviridae family in hepacivirus genome. HCV effect liver that develop in CHC contagion in maximum patients. About 160 million individuals are infected by HCV contagion that leads Long-lasting hepatitis C, liver cirrhosis, hepatocellular carcinoma. Direct damaged hepatic cells by HCV cause CHC and Chronic Hepatitis C leads lipid accumulation in liver. Objective: To evaluate the lipid peroxidation and Hepatic profile in hepatitis C patients receiving ribavirin and sofosbuvir. Methodology: Venous blood samples (5.0 ml) of 50 diagnosed Hepatitis C patients receiving sofosbuvir and ribavirin and 50 Blood samples (5.0 ml) of Healthy individuals were taken in clotted gel vials. Blood serum was further tested for estimation of Malondialdehyde (MDA), Nitric Oxide (NO), Advanced Glycation End products (AGE’s), Serum Liver Functions tests (LFTs), Lipid Profile, Urea and Creatinine by using spectrophotometer. Results: Serum MDA level significantly elevate (8.60) in diseased individuals receiving sofosbuvir and ribavirin than control (1.3) and NO level significantly increase in patients (35.21) as compare to healthy individuals (6.41). Serum hepatic profile status reveals that value of ALT significantly rises in disease persons (44.56) that control individuals (36.22). Serum AST level increase significantly in diseased individuals (40.33) as compare to healthy individuals (29.81). All parameters showed significant statistically (P = 0.000 < 0.05). Conclusions: Due to high lipid peroxidation, serum MDA level and NO level elevated remarkably in Hepatitis C patients that is highly significant. AGE’s level and Creatinine level decreased in Hepatitis C patients. ALT, AST, ALP, Total Bilirubin, Urea, Cholesterols and Triglyceride level increased in HCV patients that may leads to the progression of disease. Key Words: HCV, Ribavirin, Sofosbuvir, ALT, AST, MDA
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Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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