Petrov Yu.A and Kupina A.D.
Aim. The purpose of this study was to study the content of Barr's chromatin body and the characteristics of the mitotic regime of endometrial cells when using silver-containing intrauterine contraceptives for a different time period: from 6 months to 7 years. Materials and methods. The study involved 160 healthy women, with an average age of 30 years (± 1,5). Endometrial scrapings were taken on the 8-10th or 19-23rd days of the menstrual cycle immediately after removal of silver-containing IUDs. For the study, cases were selected in which the uterine mucosa was without pathological changes. The control was the endometrium obtained in 30 women before the introduction of silver-containing IUD using the scratch biopsy (on the corresponding days of the cycle). For the study, cases were selected in which the uterine mucosa was without pathological changes. The control was the endometrium (scratch biopsy) obtained in 30 women before the introduction of silver-containing IUDs (on the corresponding days of the cycle). The mitotic regimen was studied on histological sections 6–9 μm thick, stained with Heidengain’s iron hematoxylin. Results. During the study it was found out that the content of Barr's chromatin did not undergo significant changes characteristic of proliferative processes of the uterine mucosa. Only in the group of women who used silver-containing IUDs for up to 1 year, the decrease in the mitotic activity of epithelial cells and endometrial stroma was detected, but it was transient. The analysis of the mitotic regime of epithelial and endometrial stroma cells with the use of silver-containing IUDs showed that the ratio of the number of prophases and metaphases, the number and spectrum of pathological mitoses did not differ significantly from the control group. Keywords: silver-containing intrauterine contraceptive devices, Barr's chromatin, proliferative processes, mitotic regime, pathological mitoses.