- CODEN : IAJPBB
- issn 2349-7750
TITLE:
THE ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF DOMPERIDONE AND CINNARIZINEBY USING RP- HPLC
AUTHORS:
B. Vemalakshmi* ,Dr.N. Neelima, Chaitanya Bangari , Dr.M.B.Venkatapathi Raju
ABSTRACT:
The system suitability the % RSD for the peak area of domperidone and cinnarizine were found to be 0.100016 and 0.040736 respectively. For regression coefficient for both the drugs in linearity was found to be 1,Y- intercept for domperidone and cinnarizine were found to be -73286 and -92028 respectively. The individual % assays of domperidone and cinnarizine for system precession were found to be between 98-102.The % RSD of domperidone and cinnarizine were found to be 0.094872 and 0.014023 respectively. In intermediate precision the individual % assays of domperidone and cinnarizine were found to be between 98 to102. The % RSD of domperidone and cinnarizine of analyst 1 were found to be 0.065945 and 0.024433 respectively. The % RSD of domperidone and cinnarizine of analyst 2 were found to be 0.082395 and 0.030517 respectively. For accuracy the percentage mean recovery of 80 % domperidone and cinnarizine were found to be 99.98577 and 100.062 respectively, 100% domperidone and cinnarizine were found to be 100.0181 and 99.9292 respectively,120 % domperidone and cinnarizine were found to be 99.84517 and 99.9976 respectively. For Ruggedness for system-1 the %RSD of domperidone and cinnarizine were found to be 0.079988 and 0.032579 respectively and % assay of domperidone and cinnarizine were found to be 99.99 and 100.07 respectively. For system-2 the %RSD of domperidone and cinnarizine were found to be 0.061879 and 0.026339 respectively and % assay of domperidone and cinnarizine were found to be 99.94 and 99.93 respectively. The LOD of domperidone and cinnarizine were found to be 1.055929 and 0.656951968 respectively. The LOQ of domperidone and cinnarizine were found to be 3.199785 and 1.990763538 respectively. Keywords: domperidone ,cinnarizine , regression coefficient , accuracy and Ruggedness
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
Indexed In
S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
Cover Page
