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TITLE:

CORRELATION BETWEEN SERUM LIPID FRACTIONS AND RADIOLOGICAL SEVERITY IN PATIENTS WITH DRUG‑RESISTANT PULMONARY TUBERCULOSIS: A CROSS‑SECTIONAL PILOT STUDY

AUTHORS:

Dr.Farzeen Safdar, Dr.Irum Tariq, Dr.Muhammad Kaleem Abbas Gurmani

ABSTRACT:

Objective- The aim of this study is to determine that either body mass index and serum cholesterol that are very significant in maintaining immunity have any impact on serum lipid fraction and radiological severity in patients with TB. Methodology- This is a cross sectional study which was conducted in Bahawalpur Victoria hospital over the period of two years in patients who was newly diagnosed with drug-resistant tuberculosis. To determine the radiological severity chest X-ray scoring formula was used. Using the coefficient of Pearson’s correlation in chest X-ray, BMI and lipid fraction level was determined. Result-For this study 35 patients were selected. In this study between chest X-ray and BMI (P = 0.044, r = −0.352), low‑density lipoprotein‑cholesterol (P = 0.012, r = −0.431), high‑density lipoprotein‑cholesterol (P = 0.005, r = −0.479) and total cholesterol (P = 0.001, r = −0.546) significant negative relation was found. Conclusions- An increased radiological severity is associated with the low BMI and low serum cholesterol level that in return can increase the infectivity. This severity can be potentially decreased by using the proper nutrients supplements in diet and by this prevalence of drug resistant tuberculosis and transmission of this can also be decreased. Keywords: Radiography, infection transmission, drug‑resistant tuberculosis, cholesterol

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