::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

DEFICIENCY OF VIT D AND ASSOCIATED RISK FACTORS IN ACUTE RHINOSINUSITIS (ARS)

AUTHORS:

Dr Hafsa Khalid,Dr Shifa Nayyab, Dr Ifrah Amjad Mir.

ABSTRACT:

The most common problem seen in pediatric group is acute rhinosinusitis (ARS). Almost 1 million outpatient visits opd annually. Recent guidelines and clinical criteria have set out for the diagnosis and treatment. The complications of ARS has classified according to the Chandler classification system such as presential periorbital cellulitis, postseptal orbital cellulitis, subperiosteal and orbital abscess, cavernous sinus thrombosis, and intracranial complications. The initial step of the pathogenesis in ARS is mucosal inflammation. It causes blockage in the ostiometal complex and ciliary dysfunction. This blockage causes pool of secretions within the sinonasal cavities which is the prime cause of bacterial/viral or fungal infection. The study has concluded that low 25OHD levels are associated with ARS development and complications. There is more literature needed to reveal the underlying mechanism. Furthermore, high-quality, randomized controlled studies are needed to determine whether or not vitamin D supplementation in children with low vitamin D status affects the incidence and complications of ARS in the general population.