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TITLE:

A COMPARATIVE STUDY OF EFFICACY OF TAMSULOSIN VERSUS ALFUZOSIN FOR THE EXPULSION OF URETERIC STONES’’

AUTHORS:

Dr. Mubeena Javed, Dr. Hammad Yousaf Khan Niazi, Dr. Aisha Saif

ABSTRACT:

Introduction: The aim of the study is to compare the efficacy of Tamsulosin and Alfazocin for the removal of ureteric stone. Methodology: Study Design: Comparative Study Setting: The study will be conducted at Jinnah Hospital, Lahore. Sample Size: Sample size of 206 cases; 119 cases in Tamsulosin group and 87 cases in alfzocin was calculated by 95% confidence level with 80% power of test and taking magnitude of efficacy as 86.2% with tamsulosin (Ahmed and Al-sayed, 2010) and 68% with alfuzosin. Results: once daily for 28 days or till spontaneous stone passage (which ever was first). Results: The average age of Tamsulosin patients was 35.8±10.4 years with the minimum and maximum ages 19-59 years respectively(Table 1). The average age of Alfazocin patients was 41.4±11.4 years with the minimum and maximum ages 24-77 years respectively(Table 5). The average stone size in group I was 6.63±1.45 mm and in group II it was 6.93±1.39 mm. The range of stone size in group I was 4.5 -9mm and in group II it was 5 -10mm. In group I the stone was discharged in 65 out of 119 patients and in group II stone was discharged in 45 out of 87 patients only. The average expulsion time in group II was significantly less than group I [P = 0.001] Conclusion: Alpha 1 antagonist (Tamsulosin) increases spontaneous expulsion of small distal ureteral stones. Keywords: Efficacy, Lower ureteric stone, shock wave lithotripsy, ureteroscopy

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