Dr Nouman Shafique, Dr Muhammad Tehseen Ali, Dr Farhan Ghaffar Bhatti
Aim: To differentiate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia and to Isolate Terminal deoxynucleotidyl transferase positive blasts in CSF. Place and Duration: In the Oncology department of Mayo Hospital Lahore for one year duration from March 2019 to March 2020. Methods: The study covered 35 persons. They were divided into three groups. They were elected from the Mayo Hospital, Lahore. 35 cases were divided into three groups: - Group A included 25 patients with acute lymphoblastic leukemia. Patients from group B 05 with acute myeloid leukemia and patients with a normal control group from group C 05 subjects. Results: Patients with Acute lymphoblastic leukaemia (Group A) had Terminal deoxynucleotidyl transferase positive blasts in peripheral blood smear while acute myeloid leukaemia (Group B) had no Tdt+ve Blasts in peripheral blood smear. Out of 25 patients of ALL, 06 (24%) patients of ALL had TdT positive blasts in Cerebrospinal Fluid Staining. Keywords: Terminal deoxynucleotidyl transferase (TDT), ALL, AML.