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Dr Fatima Akram, Dr. Mahnoor Arshad, Dr Shafaq Naseer
When the birth period is completed in the females, we observe the lessening of number of chromosomes containing partial somatic cells in the female’s reproductive organ. Prior to birth, half of the follicle puddle is misplaced. Pending the females arrives at the 40 years of age, atresia sluggish, at that time the number of follicles stayed arrives at a dangerous doorstep. Again, atresia becomes fast at this stage again and female developed through the reproductive aging until when no eggs in the ovary of female present more. This occurs at the average age of 51 years. We notice the less formation of B inhibin and almost no secretion of follicle stimulating hormone (FSH) when only smaller numbers of ovaries are present in the female body. A large number of hormonal discharges occur on the basis of reaction towards follicles in every periodic cycle. Sometimes females face unsuitable production of follicles and sometimes normal production. These two conditions alternate simultaneously. A study named Study of Women across the Nation (SWAN) was organized to recognize the changes in the hormonal discharge of the females. This recognition was made by examining the urine of the female every day. It was observed that females of the larger ages and larger weight bearing showed less discharge of hormones. Less production of estradiol and more release of FSH was seen in the older females at the time stoppage of reproductive cycle. At the time of start of menopausal evolution less production of luteinizing hormone was also observed. Central nervous system of the female fails to react normally towards the secretion of various hormone so imbalance in the production of hormones results. Throughout the evolution we noticed the changes in every reproductive cycle, not only the ovary. Changes in the hormonal secretion of reproductive cycle indicate the perimenopause. Place and duration: In the pathology and obstetric department of Ganga Ram Hospital Lahore for one-year duration from March 2019 to February 2020. Keywords: An ovulation; FSH; Inhibin; Menopausal transition; ovarian aging