::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

MATERNAL SERUM URIC ACID LEVELS AT DELIVERY IN GESTATIONAL HYPERTENSIVE WOMEN

AUTHORS:

Dr Shabana, Dr Silwana Taroni, Dr Gul Nazar

ABSTRACT:

Background and objectives: The most common reason for such a high maternal and perinatal morbidity and mortality associated with HDP is the unavailability of precise and specific test that can identify pregnant women at risk of developing HDP. The basic aim of the study is to analyze the maternal serum uric acid levels at delivery among gestational hypertensive women and its effect on fetal growth. Material and methods: This descriptive study was conducted in Rawalpindi Medical College during June 2019 to January 2020. The data were collected from 100 pregnant female patients with gestational age above 32 weeks. The selected participants were divided into 2 groups, one with GH and second group with NP. All the participants were age matched.GH is defined as denovo hypertension with systolic blood pressure (SBP) ≥140 mmHg and diastolic blood pressure (DBP) ≥90 mmHg after 20 weeks of gestation.PE is GH with proteinuria – 1+ on dipstick or ≥300 mg/day or Pr:Cr ratio as ≥3.0 mg/g. Results: The data was collected from 100 randomly selected participants. The mean age for NP were 23.2 ± 2.9 and for GH 22.9 ± 3.0. The mean age and gestational age among both groups were not statistically significant. SBP, DBP, and urinary proteins were significantly different in the both groups. The mean serum uric acid and creatinine levels were significantly elevated in GH (4.27 ± 1.0 mg/dL; 0.66± 0.19 mg/dL) and NP (4.25 ± 0.8 mg/dL; 0.63 ± 0.13 mg/dL).In NP group, 67% women had full-term normal vaginal delivery (FTNVD). Conclusion: It is concluded that Serum uric acid and creatinine are elevated in GH whereas no significant difference was observed between PE and NP.