::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

INFLUENCE OF TRANSFUSION OF BLOOD ON FUNCTIONS OF KIDNEYS IN THE PATIENTS UNDERGOING TOTAL KNEE ARTHOPLASTY

AUTHORS:

Muhammad Arsalan Ali, Dr Abdullah Sarwar, Dr Nida Pervaiz

ABSTRACT:

Objective: Different research works have investigated the impacts of peri-surgical transfusion of blood on the functions of kidneys. In this current research work, we examined the perioperative transfusion of blood on the functions of kidneys in the patients who were undergoing Total Knee Arthroplasty. Methodology: This study was retrospective research work conducted on 216 patients who had undergone total knee arthroplasty from March 2018 to December 2019. The division of the patients was carried out into 2 groups in accordance with the level of transfused blood utilized during surgical intervention. There were 72.70% (n: 157) patients in the Group-1 requiring the blood transfusion of < 3 units, whereas 27.30% (n: 59) patients were present in Group-2 needed 3 or more units of blood. Results: We examined no statistical difference in the patients of both groups regarding HTN (Hypertension) before surgical intervention, DM (Diabetes Mellitus), failure of kidney, habits of cigarette smoking and disease of lungs(P> 0.050). Similarly, there were no significant differences associated to pulmonary or other abnormalities or mortality of the patients (P> 0.050). When the comparison of the groups was carried out, we found no statistical difference in the functions of kidneys or other systems of body (P > 0.050). Conclusions: There is no negative impact of transfusion of blood on the postsurgical levels of BUN (Blood Urea Nitrogen) and creatinine, or GFR (Glomerular Filtration Rate) in total knee arthroplasty. KEYWORDS: Total Knee Arthroplasty, Creatinine, Postsurgical, Intervention, Kidney, Transfusion, Blood, Blood Urea Nitrogen, Diabetes, Hypertension, Lungs.