Maryam Waheed Khan, Dr Syeda Fatima Murtaza, Iqra Mazhar
Purpose: Dengue, a mosquito-borne arbovirus, comes from dengue serotypes belonging to the Flaviviridae family (DEN-1, DEN-2, Den-3, DEN-4). The purpose of this study is to examine the clinical-pathological profile of dengue shock syndrome in comparison with other types of children in a tertiary health center. Methods: This observational cross-sectional study was conducted in the Pediatric Unit II of Jinnah Hospital Lahore for one-year duration from March 2019 to February 2020 after approval by the Corporate Ethics Committee. Chi-square statistical analysis, ANOVA, paired t 22 SPSS version test (IBM SPSS Statistics, Somers NY) was used for Data analysis. Results: The average age of patients was 8.08 ± 2.72 years, the majority of cases were females (51.9%) and 48.1% males, clinical features such as hepatomegaly and ascites associated with pleural effusion were significantly present in DSS (p <0.001). The study showed no significant difference in dengue symptoms and severity, except for one seizure. Thrombocytopenia (platelets <1 lakh / cmm) in 74% of cases, leukopenia in 56% (total number of leukocytes <4000 / cmm), more than 40 hemocytes were observed in 21.27% of cases. There was acute kidney damage, TLC and encephalopathy in Dengue syndrome. Observations of complications between dengue severity were statistically significant. There was a significant difference in hematocrit values between the three dengue diagnoses from day 1 to day 4. Initially a higher hematocrit was observed in the dengue shock syndrome, and this decrease continues to decrease. Conclusion: According to our research, it can be concluded that dengue shock syndrome is acute kidney damage, TLC and encephalopathy. There was a significant difference between the hematocrit values between 1 and 4 days between the three dengue fevers. Initially, higher hematocrit was observed in dengue shock syndrome. Key words: dengue complication, dengue hemorrhagic fever (DHF), dengue shock syndrome (DSS), laboratory profile of dengue fever.