::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CIRCULATING SERUM BIOMARKERS FOR PROGRESSION AND SURVIVAL PREDICTION IN BREAST CANCER

AUTHORS:

Dr. Mariam Fatima, Dr. Syed Muhammad Arslan, Dr. Areeba Maryam

ABSTRACT:

Background and objectives: Cancer is a leading cause of mortality and morbidity worldwide, counting for 7 million deaths per year. This study aimed to assess the circulating biomarkers for survival in the prediction of breast cancer in females. Methodology of the study: This descriptive study was conducted in Bahawal Victoria Hospital, Bahawalpur during June 2019 to January 2020. The main eligibility requirements for this study included the patient's written informed consent, metastatic breast cancer, patients entering first-line chemotherapy with or without targeted therapy, life expectancy of at least three months, and measurable or evaluable disease. Results: The results indicate that CTC, CEA and ALP are the best indicating serum biomarkers for the diagnosis and progression of breast cancer. Mean, median and SD shows that there is a significant relationship in these serum biomarkers. Conclusion: It is concluded that CTC and ALP are the important biomarkers for the analysis of progression of breast cancer in females.