::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EFFECT OF COENZYME Q 10 ON ADIPONECTIN, OXIDATIVE STRESS AND GLYCAEMIC CONTROL IN PATIENTS WITH TYPE II DIABETES MELLITUS

AUTHORS:

Dr Zainab Hooria, Dr Ahad Sharif, Dr Natasha Maryam

ABSTRACT:

Aim: To evaluate the effect of coenzyme Q10 supplementation on glycemic control, oxidative stress and adiponectin levels in type 2 diabetic patients. Methods: A randomized, single-blind, placebo-controlled study was conducted in people with type 2 diabetic patients. Patients and controls received 100 mg coenzyme Q10 or placebo twice daily for eight weeks. Various measurements were made at the beginning and end of the intervention. These include markers for measuring glycemic control (fasting blood sugar and glycated hemoglobin); an oxidative stress marker (malonic aldehyde); and anti-inflammatory marker (adiponectin). SPSS 18 was used for statistical analysis. Results: Out of 52 patients, 28 (54%) were male and 24 (46%) were female, and the average age was 51.73 ± 7.34. In the intervention group there were 16 (62% men and 10 (39%) women), 12 (46%) men and 14 (54%) women in the control group, which resulted in a significant reduction of coenzyme Q10 and the difference was not significant (p> -0.05). In addition, fasting blood glucose, glycosylated hemoglobin and adiponectin did not show significant differences within or between groups (each p> 0.05). Conclusion: Coenzyme supplementation may reduce oxidative stress in patients with type 2 diabetes, but may not have an effect on glycemic control and adiponectin levels. Key words: coenzyme Q10, diabetes, blood sugar, oxidative stress, inflammation.