Dr.Anjum Zahra, Dr. Saad Muhammad, Dr. Muhammad Yaseen
Aim: To measure very sensitive blood levels of C-reactive protein and ferritin in the blood, and to assess its association with inflammation in people with type 2 diabetes. Method: Case control study was conducted at the Medicine Unit II of Nishter Hospital Multan for one year duration from February 2019 to February 2020, and included randomly selected patients and healthy controls. Fasting blood samples were analyzed to determine blood sugar, insulin, very sensitive C-reactive protein and iron status. SPSS 19 was used for statistical analysis. Results: Out of 210 originally selected patients, 99 (47%) were excluded from the study due to anemia. The study population is 111 (53%) with a total average age of 38.6 ± 1.56 years, and fasting blood sugar is 110.78 ± 3.795 mg / dl. In group 1, there were 44 (39.6%) healthy people and 67 (60.3%) diabetic patients in group 2. High serum ferritin (233.11 ± 43.84 ng / ml), insulin (29, 94 ± 2.19), insulin homeostasis pattern, resistance (10.23 ± 0.89) and very sensitive C-reactive protein (5.29 ± 0.80 mg / L) low serum iron levels (5.29 ± 0 , 80 mg / L) 1.07 ± 0.115 µg / dl) in group 2. The insulin resistance homeostasis model showed a positive correlation with fasting blood sugar (r = 0.596; p <0.009). There was a negative correlation with iron serum (r = -0.280; p <0.016) and transferrin saturation (r = -0.316; p <0.006). Conclusion: Increased ferritin levels without visible iron overload can affect glucose homeostasis and lead to insulin resistance with inflammatory changes, as seen at high levels of C-reactive protein. Key words: ferritin, hs-CRP, T2DM, insulin resistance.