::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ANALYSIS OF ANTIOXIDANTS LEVEL IN DENGUE FEVER

AUTHORS:

Dr. Hina Mumtaz, Dr. Humaira Noreen, Dr. Aisha Fiaz

ABSTRACT:

Introduction: Dengue is the most frequent viral infection, with > 100 million infections throughout the world annually, including 250,000–500,000 cases of dengue hemorrhagic fever (DHF) and 24,000 deaths. Objectives of the study: The main objective of the study is to analyse the levels of antioxidants in dengue fever among local population of Pakistan. Material and methods: This cross-sectional study was conducted in Nishtar Hospital, Multan during June 2019 to December 2019. The data was collected from 100 patients of both genders. Antioxidants levels in the blood were measured by getting blood samples of patients. 5cc blood sample was taken and then it centrifuged at 4000rpm for the separation of serum. Results: The data was collected from 100 patients of both male and female patients. SOD activity in the serum and liver was dramatically and significantly decreased after infection when compared to normal values. MDA levels in the serum were significantly elevated when compared to the controls (p<0.05). CAT activity in the liver showed a significant decrease when compared with the controls (p<0.05), whereas there was no obvious change in CAT levels in the serum. Conclusion: It is concluded that dengue viral infection results in a significant alteration in the oxidative status in the liver, as shown by increased ROS production, MDA levels and the GSSG/GSH ratio and decreased levels of SOD and CAT.