::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EFFECTIVENESS OF HYDRALAZINE IN DECREASING THE BLOOD PRESSURE IN CASE OF SEVERE HYPERTENSION DURING PREGNANCY PERIOD

AUTHORS:

Dr. Hamara Altaf, Dr. Nida Hafeez, Dr Saira Arif

ABSTRACT:

Objectives: This research work aimed to determine the protection and effectiveness of hydralazine in decreasing the BP (Blood Pressure) in case of severe HTN (Hypertension) in the duration of pregnancy. Methodology: In this research work, the inclusion of the pregnant patients with SBP (Systolic Blood Pressure) of 160.0 mmHg or greater and DBP (Diastolic Blood Pressure) 109.0 mmHg present with eclampsia and in emergency condition of HTN carried out. The starting hydralazine dose was 5.0 milligrams IV bolus then repeated one milligram at an interval of twenty minutes. The measures of the outcome to start the therapy were, SBP, DBP, duration needed to achieve desired level of BP, requirement of total dose, side effects of medicines and feto-maternal outcomes regarding safety and effectiveness of the used medicine. Results: Total 110 patients suffering from eclampsia and HTN emergencies were the participants of this research work. The average age of the mothers was 26.70 ± 6.70 with a range from 18 to 45 years. Before the start of the treatment SBP was 165.50 ± 16.65 mmHg, and DBP was 115.44 ± 8.25 mmHg. After the start of the treatment, an important difference (P = < 0.0010) was detected with decrease in SBP 131.20 ± 9.49 mmHg and in DBP as 93.680 ± 6.30 mmHg. In 85.50% (n: 94) patients, sixty minutes were taken by IV bolus hydralazine, however, in 2.70% (n: 3) patients, there was requirement of more than three hours to control BP. The total dose of medicine needed was less than six milligram in 38.40% (n: 40) patients, 6.0 to 14.0 milligrams in 40.0% (n: 44) patients and in 15.50% (n: 17) patients, 15.0 to 20.0 milligrams dose was the requirement to control BP. Only 8.18% (n: 9) patients required medicine between 21.0 to 30.0 milligrams IV bolus hydralazine. Conclusion: Hydralazine is much secure and effectual drug to control the BP in severe HTN in the duration of pregnancy as well as after delivery. KEY WORDS: Mortality, hydralazine, HTN, milligrams, mmHg, BP, SBP, DBP, eclampsia, methodology.