- CODEN : IAJPBB
- issn 2349-7750
TITLE:
THE EFFECT OF HYDROALCOHOLIC EXTRACT OF DRACOCEPHALUM KOTSCHYI ON ELECTROPHORETIC PATTERN AND BLOOD IMMUNOGLOBULINS OF LABORATORY MICE
AUTHORS:
Elaheh Rostami, Mehrdad Modaresi *, Habibollah Nazem
ABSTRACT:
Dracocephalum kotschyi is one of the medicinal plants that is involved in the treatment of many diseases and contains flavonoids, monoterpene, terpenoids, phytosterol and beta-caryophyllene compounds. This study was carried out to investigate the effects of Dracocephalum extract on blood immunoglobulins of female mice (Balb/C race). Fifty mice were divided into five groups: control, placebo, and extract groups at doses of 50, 100 and 200 mg/kg of body weight. Hydroalcoholic extract was injected intraperitoneal every two days for 20 days. Biochemical blood tests were performed using protein electrophoresis. The indices evaluated were albumin, beta-globulin, alpha-1-globulin, alpha-2-globulin, gamma-globulin, and the ratio of albumin to globulin. Results showed increased levels of albumin in the 50 mg/kg and 200 mg/kg groups, alpha-1 in 50 mg/kg group and alpha-2 in all groups. Beta-globulin was significantly decreased in 50 and 100mg/kg groups compared to the control group. Gamma globulin amount was decreased in 50 mg/kg but increased by 100 and 200 mg/kg groups. The ratio of albumin to globulin was significantly decreased in 100mg/kg group compared to control group. According to the results, the extract can affect blood proteins, dose dependently and it has different effects at different doses, which emphasizes the proper use of herbs. Keywords: hydroalcoholic extract, Dracocephalum kotschyi, immune system, laboratory mice
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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