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TITLE:

STUDY TO DETERMINE THE RELATION OF WBC COUNT AND DURATION OF SYMPTOM TO PREDICT DISEASE SEVERITY IN PATIENTS OF ACUTE APPENDICITIS

AUTHORS:

Dr. Aayan Asghar, Dr. Muhammad Arif, Dr. Irfan Mureed

ABSTRACT:

Aim: To determine the relationship between the severity of acute appendicitis and the number of white blood cells, age and duration of symptoms. Study design: cross-sectional study. Place and duration: In the Surgical Unit II of Jinnah Hospital Lahore for one year duration from March 2019 to March 2020. Method: The study involved 242 patients with clinical and histological diagnosis of acute appendicitis. Patients with simple acute appendicitis, purulent appendicitis, perforated appendicitis, or gangrenous appendicitis were included. Histological verification was performed on all samples. Results: Of the 242 patients, 174 are men and 68 women. The mean duration of symptoms was 1.98 ± 1.83 days in men and 1.52 ± 0.81 days in women. The mean duration of symptoms for simple acute appendicitis (Group 1) was 1.92 ± 1.71, 1.38 ± 0.5 for purulent appendicitis (Group 2) and 1.38 ± 0.69 for perforated appendicitis (group 3). Average white blood cell counts for simple acute appendicitis, purulent appendicitis, and perforated appendicitis were 10,907.11 ± 3029.56, 10300 ± 2401.38 and 12461.11 ± 3643.22 respectively. No gangrenous cases of appendicitis were observed. Patients aged 25 to 35 years had the highest number of white blood cells in various groups of acute appendicitis (P = 0.004). No gangrenous cases of appendicitis were observed. There was no significant correlation between the number of white blood cells and the severity of appendicitis symptoms. There was a significant relationship between different age groups and the severity of the disease (p = 0.042). Conclusion: WBC numbers and duration of symptoms are not good predictors of disease severity in appendicitis. In the adult population, an increase in age even under 45 years increases the risk of appendicitis complications. Key words: appendicitis, complications

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