::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

SILVER-CONTAINING INTRAUTERINE DEVICES AND HYPERPLASTIC CHANGES OF ENDOMETRIUM

AUTHORS:

Petrov Yu.A and Kupina A.D.

ABSTRACT:

Aim. The purpose of this study was to study the frequency and features of endometrial hyperplastic processes, endo- and ectocervix in women using silver-containing IUDs for a different period of time: from 3 months to 7 years. Materials and methods. The study involved 450 women who used silver-containing IUDs from 3 months to 7 years. The histological examination of scrapings was performed, as well as the cytological examination of smears from the cervix and the lower third of the cervical canal. The control group consisted of 270 patients (not using contraception) aged 21–45 years who underwent colpositological examination, 65 of them underwent scratch biopsy (before installing silver-containing IUDs). Histological sections were stained with hematoxylin and eosin (Felgen), cytological preparations were stained with azure-eosin. The content of Barr's chromatin body and the features of the mitotic regime of glandular epithelial cells were studied and compared with normal endometrial cells of the middle proliferation stage. Barr's chromatin body counting was performed in slices with the Felgen’s reaction with the increase of up to 1200 times. Results. During the study it was found out that silver-containing IUDs did not increase the frequency of precancerous processes and cervical cancer and did not lead to the development of endometrial cancer. In addition, some features of the proliferative processes of the mucous membrane of the body and cervix were established in women with silver-containing IUDs. Keywords: silver-containing intrauterine contraceptive devices, hyperplastic processes, mitotic regime, ectocervix, endocervix.