- CODEN : IAJPBB
- issn 2349-7750
TITLE:
ASSOCIATION OF BILIRUBIN LEVELS WITH LIVER ENZYMES IN FALCIPARUM MALARIA AFFECTED PATIENTS
AUTHORS:
Dr Hafiz Ahmad Sami, Dr Kainat Liaqat, Dr Muhammad Jahanzaib Sabeeh
ABSTRACT:
Introduction: Malaria Falciparum is responsible for 1-3 million deaths worldwide each year. Liver involvement is common and may occur as high serum bilirubin, liver enlargement and high liver enzymes. Unconjugated hyperbilirubinemia has often been shown to increase mortality. Alanine aminotransferase (SGPT) is an indicator of liver damage. This study was conducted to observe a correlation between liver enzymes and bilirubin in patients with malaria Plasmodium falciparum. Aim: To observe the correlation coefficient of bilirubin with liver enzymes (SGPT, SGOT and alkaline phosphatase) in patients with malaria falciparum. Project: A Descriptive study Place and duration of the study: In the Medicine department of Akhtar Saeed Trust Teaching Hospital, Lahore for one year duration from January 2019 to January 2020. Materials and methods: 81 patients of both sexes and acute malaria were selected by appropriate sampling. Nine patients with hepatitis B and C infection were excluded from the study. In the remaining 72 cases, 48 (70%) had Plasmodium falciparum infection and 24 (30%) had Plasmodium vivax infection. Falciparum infected patients were divided equally into two groups depending on the duration of the disease. Group I lasted from 1 to 7 days, group II from 8 to 20 days. Patients with Plasmodium vivax infection lasted from 1 to 20 days and were placed in group III. Results: Group I showed a statistically significant positive correlation with SGPT and alkaline phosphatase bilirubin (r = 0.50 and r = 0.054), and SGPT showed excellent positive correlation in group II (p <0.05). r = 0.88; P <0.01), SGOT and alkaline phosphatase also showed a statistically significant positive correlation, while in group III both transaminase and alkaline phosphatase showed a statistically significant positive correlation r = 0, 82, 0.63 and 0.69. Conclusion: A positive correlation between liver enzymes and bilirubin suggests that an early diagnosis of Plasmodium falciparum malaria infection should be made to prevent complications and reduce mortality. Key words: malaria, liver enzymes, bilirubin, malaria falciparum
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NLM ID:101711216 [Serial]
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ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
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IP Indexing Impact Factor: 2.76
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