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GENETICS FACTORS BEHIND THE OCCURRENCE OF HYPERTENSION: SYSTEMATIC REVIEW IN LITERATURE

Israa Alfadhli* , Ahmed Alharbi , Imtinan Alhazmi , Wed Alluhaibi , Hasna Emam , Mohammed Alqithami , Fatima Rajab , Asma Almatrafi , Anwaar Basri , Mishal AlArifi

This review is aiming to discuss the Genetics factors which lead to the occurrence of HTN. The present review was conducted by searching in Medline, Embase, Web of Science, Science Direct, BMJ journal and Google Scholar for, researches, review articles and reports, published over the past years during the period from 3 of August 2018 to 7 October 2018 . Books published on the Genetics factors of HTN. If several studies had similar findings, we randomly selected one or two to avoid repetitive results. On the basis of findings and results this review found The heritability of blood pressure (BP) is estimated to be 30–50%. A great effort was made to find genetic variants affecting BP levels through Genome-Wide Association Studies (GWAS). This approach relies on the “common disease–common variant” hypothesis and led to the identification of multiple genetic variants which explain, in aggregate, only 2–3% of the genetic variance of hypertension. Keywords: HTN , Genetics, essential hypertension; blood pressure; genome-wide association studies; nextgeneration sequencing; rare variants; rare-variants association testing; burden test; sequence kernel association test

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