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CLINICAL MANAGEMENT OF NON-STEROIDAL ANTIINFLAMMATORY URTICARIA/ANGIOEDEMA PATIENTS

Dr. Amar Salman, Dr. Rai Adnan Ahmad, Dr. Adeel Ismail

In the large majority of previous studies, patients with a history of acute urticaria induced by non-steroidal antiinflammatory drugs (NSAIDs) seeking safe alternative drugs have undergone tolerance tests uniquely with compounds exerting little or no inhibitory effect on the cyclooxygenase 1 enzyme. In light of recently published studies, however, this approach seems inadequate and should be changed. The present article critically reviews the clinical management of patients presenting with a history of urticaria induced by a single NSAID or multiple NSAIDs and suggests a simple, updated diagnostic algorithm that may assist clinicians in correctly classifying their patients. Key words: aspirin, drug allergy, non-steroidal anti-inflammatory drug, urticaria

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