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ANTI-HYPERLIPIDEMIC ACTIVITY OF LEAF EXTRACTS OF ALANGIUM LAMARKII LINN IN TRITON-INDUCED AND ATHEROGENIC DIET INDUCED HYPERLIPIDEMIC WISTAR ALBINO RATS.

S. Janet Beula, Dr.R.Suthakaran, Rajaram Das, Laxmidhar Sahoo and D.Swetha

Energy storage, signalling act as structural components of cell membrane are the main biological function of lipids. Elevated serum total cholesterol (TC), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and decrease high density lipoprotein (HDL), are major risk factor for coronary heart disease and atherosclerosis. Medicinal herbs or their phytoconstituents are currently used for their lipid lowering activity and reduce the production of reactive oxygen species and increase the resistance of plasma lipoprotein to oxidation to their effectiveness at preventing cardiovascular disorder. The importance of herbal medicine practices is indicated by the fact that about 80% of the developing World’s population depends on traditional medicine for their primary healthcare. Hyperlipidemia is a secondary metabolic dysregulation associated with diabetes. In India Alangium lamarkii Linn. (Alangiaceae) commonly used as a phyto-therapeutic agent. The methanolic extract of Alangium lamarkii was evaluated for anti-hyperlipidemic effect, induced by intraperitonial administration of Triton in Wistar Rats. The Alangium lamarkii extract significantly (p<0.01, P<0.05) reduced the plasma L.D.L, triglyceride level and raised the plasma H.D.L level. All these observations provided the basis for conclusion that this plant extract inhibits lipid content induced by Triton treatment in rats. Keywords: Alangium lamarkii Linn. Alangiaceae, Phytochemical, anti-hyperlipidemic, methanolic extract.

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